Endocrine Abstracts

Introduction: Diabetic nephropathy (DN) is a severe complication of type 1 diabetes mellitus (T1DM) and has become common primary disease leading to end-stage renal disease worldwide. Abnormalities in lipid metabolism is very important in the progression of renal damage in patients with T1DM.Aim: to assess the relationship between lipid abnormalities and diabetic nephropathy in type 1 diabetes mellitus patients. Methods: we perform...

Introduction: 45,X karyotype is known to be related to more severe phenotype disorders, still comparative analysis of the karyotypes and phenotypes in Turner syndrome (TS) is difficult, even in the largest studies, mainly due to differences in patient‘s age and variability in the definition of clinical features (1). We aimed: to assess if monosomia in Turner syndrome patients is related to their cardiometabolic features.Methods: 75 females with conf...

Objective: Misclassification of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) is quite common and crucial to choice of appropriate therapy. The aim of the study was to evaluate the correspondence of islet antigen-2 (Anti IA2) and glutamic acid decarboxylase (Anti GAD65) antibodies with clinical diagnosis.Methods: The Anti IA2 and Anti GAD65 were measured in 583 patients (337 males and 246 females) diagnosed with T1DM or T2DM with not typical manifest...

The aim: Of the study was to determine the relationship between depression and anxiety symptoms and chronic diabetes complications, disease duration, glycaemic control in type 1 diabetic patients.Methods: 18–54 year old 215 patients with T1DM were enrolled in the study. Participants filled questionnaires about DM, disease duration, complications and Beck’s depression (DB) and anxiety (BA) inventory. All patients were evaluated for microvascular...

Objectives: To evaluate sexual function in women with Turner syndrome (TS) in the relation with sex hormones.Methods: The study was undertaken in Lithuanian University of Health Sciences. 65 women with genetically confirmed TS (18–45 years) were enrolled and compared with 65 age-matched healthy controls. Sexual function was evaluated using The Female Sexual Function Index (FSFI). Risk for sexual dysfunction was defined as FSFI score ≤ 26.55. B...

Introduction: Women with Turner syndrome (TS) are known to be at risk of decreased BMD (dBMD). Sex hormone replacement therapy is crucial to ensure the proper BMD formation, although the dBMD remains a problem in TS.Aim: To investigate the prevalence of decreased bone mineralization and it’s association with hormone levels in TS.Subjects: Women with geneticaly confirmed TS aged ≥ 18 year.Methods: T...

Introduction: Aortic dilation (AD) is the life threating complication of Turner syndrome (TS). The reported prevalence of AD in TS various between 12 and 39%. Factors predicting enlargement of diameter of aorta (DA) are still under investigation.Aim: To assess the prevalence of AD in TS in Lithuanian population, to evaluate the possible predictors of AD development.Methods: Forty-three patients with TS aged ≥18 year were enro...

Introduction: GH producing pituitary adenomas are associated with infertility. Hereby the first case in Lithuania, when acromegaly patient got pregnant and delivered is reported.Case presentation: 33-year-old woman visited endocrinologist complaining of secondary amenorrhoea. Due to elevated prolactin – 3016 mU/l (NR<418), bromcriptine treatment was started. The patient discontinued treatment after three months because of restoration of regular ...

The aim of the study was to evaluate vitamin D levels in Lithuanian male military conscripts and its association with PTH, osteocalcin and testosterone, body muscles and LBM percentage, as well as depression–sadness, tension–anxiety and psychological and physical quality of life.Methods: A total of 262 healthy Lithuanian male military conscripts were tested for vitamin D, PTH, osteocalcin and testosterone concentration and 155 (59.2%) of them w...

Background: The prevalence of polycystic ovary syndrome (PCOS) in adolescents is reported up to 38.9%. Obesity is a known risk factor associated with PCOS increasing the risk of metabolic syndrome (MS). Up to 25% of adolescents with PCOS may have derangements in glucose metabolism and insulin resistance (IR).Aim: To evaluate PCOS prevalence in overweight/obese adolescent girls and to assess the association with BMI, MS and IR.Metho...